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Lymphocytapheresis in chronic progressive multiple sclerosis: immunologic and clinical effects

Hauser, S.L.; Fosburg, M.; Kevy, S.V.; Weiner, H.L.

Neurology 34(7): 922-926

1984

ISSN/ISBN: 0028-3878
PMID: 6539868
Document Number: 231196
The effects of lymphocytapheresis in 5 patients with chronic progressive MS. was studied. Ten lymphocytapheresis treatments were given in 2 wk, followed by 1 treatment every 2 wk for 2-6 mo. Of 5 patients 4 had a fall in the circulating lymphocyte count during the initial treatment, and in three patients a modest lymphopenia was sustained with maintenance therapy. In patients with abnormal T4:T8 ratios, no improvement in the T4:T8 ratio occurred. There was no apparent clinical effect in this pilot study.

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