Effects of nicardipine and other Ca2+-antagonists on catecholamine transport into chromaffin granule membrane vesicles
Tachikawa, E.; Takahashi, S.; Shimizu, C.; Ohtsubo, N.; Kashimoto, T.; Takahashi, E.
Research Communications in Chemical Pathology and Pharmacology 45(2): 305-308
1984
ISSN/ISBN: 0034-5164 PMID: 6484315 Document Number: 222535
Nicardipine (10(-7)-2 X 10(-5) M) inhibited the transport of noradrenaline into chromaffin granule membrane vesicles in a concentration-dependent manner. This inhibitory effect of nicardipine was found to be appreciably stronger than that of other Ca2+-antagonists(diltiazem, nifedipine and verapamil) and was not due to the blockade of Ca2+-channel in the granule membranes.