Use of different precursors of fatty acid biosynthesis in the brain in chronic hyperphenylalaninemia
Putilina, F.E.; Osadchaia, L.M.
Voprosy Meditsinskoi Khimii 30(2): 100-103
1984
ISSN/ISBN: 0042-8809 PMID: 6146224 Document Number: 222335
The incorporation of 14C from 2-14C-acetate, 1-6-14C-glucose and 5-14-C-glutamate into fatty acids of brain lipids under chronic hyperphenylalaninemia (HPA) was investigated. A decrease of lipogenesis intensity was demonstrated in young rat brain. In the HPA a decrease in the labelling of fatty acids occurred due to inhibition of the enzymes of fatty acid biosynthesis and to disturbance of metabolic pathways involved in lipogenesis via acentyl-CoA.