Parenteral fat emulsions and immune adherence. The effects of triglycerides on red cell and neutrophil immune adherence in vitro and in vivo
Siegel, I.; Liu, T.L.; Zaret, P.; Gleicher, N.
JAMA 251(12): 1574-1579
1984
ISSN/ISBN: 0098-7484 PMID: 6700056 Document Number: 222060
Parenteral fat emulsions may not only exert nutritional effects but may also affect immune adherence phenomena and red cell morphology. Red cell immune adherence (RCIA) was increased in vitro by 0.05% to 0.1% Intralipid. RCIA was similarly increased by groundnut oil, maize oil, half-and-half cream, paraffin oil and human low-density lipoprotein fractions. Neutrophil immune adherence was increased in vitro by 0.2% to 1.5% Intralipid. The effects of fat emulsions in vivo were studied in 10 patients who received Intralipid for nutritional purposes. Red cell immune adherence was increased in 5 of 10 patients and inhibited in 4 of 10 patients. Neutrophil immune adherence was increased in 2 of 10 patients. Cytotoxic red cell transformations were evident in 5 of 10 patients. Depression of RCIA in 4 of 5 patients was associated with cytotoxic red cell transformations.