Improved growth and anemia in HIV-infected African children taking cotrimoxazole prophylaxis
Prendergast, A.; Walker, A.S.; Mulenga, V.; Chintu, C.; Gibb, D.M.
Clinical Infectious Diseases An Official Publication of the Infectious Diseases Society of America 52(7): 953-956
2011
ISSN/ISBN: 1537-6591 PMID: 21427404 DOI: 10.1093/cid/cir029Document Number: 220978
The impact of cotrimoxazole (CTX) on growth and/or anemia was investigated in 541 human immunodeficiency virus-infected, antiretroviral therapy-naive Zambian children enrolled in the Children with HIV Antibiotic Prophylaxis trial. Compared with children randomized to receive placebo, children randomized to receive CTX had slower decreases in weight-for-age (P=.04) and height-for-age (P=.01), and greater increase in hemoglobin level (P=.01). These findings argue for expanded early CTX use.
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