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Prompt initiation of ART with therapeutic food is associated with improved outcomes in HIV-infected Malawian children with malnutrition

Kim, M.H.; Cox, C.; Dave, A.; Draper, H.R.; Kabue, M.; Schutze, G.E.; Ahmed, S.; Kazembe, P.N.; Kline, M.W.; Manary, M.

Journal of Acquired Immune Deficiency Syndromes 59(2): 173-176

2012

ISSN/ISBN: 1944-7884
PMID: 22107819
DOI: 10.1097/qai.0b013e3182405f8f
Document Number: 561085
This retrospective observational study of 140 HIV-infected children with uncomplicated malnutrition in urban Malawi tested the hypothesis that initiation of antiretroviral therapy (ART) within 21 days of outpatient therapeutic feeding (prompt ART) improved clinical outcomes. Children receiving prompt ART were more likely to recover nutritionally (86% vs. 60%, P < 0.01) and had higher rates of weight gain (3.6 vs. 1.6 g/k/day; P = 0.02). Logistic regression modeling found prompt ART was associated with increased likelihood of nutritional recovery (odds ratio: 5.4, 95% confidence interval: 2.0 to 14.5). This suggests that prompt ART is associated with improved outcomes in HIV-infected Malawian children with uncomplicated malnutrition.

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