Non enzymatic glycosylation increases platelet aggregating potency of collagen from placenta of diabetic human beings
Le Pape, A.; Gutman, N.; Guitton, J.D.; Legrand, Y.; Muh, J.P.
Biochemical and Biophysical Research Communications 111(2): 602-610
1983
ISSN/ISBN: 0006-291X PMID: 6404273 Document Number: 220542
Pepsin extracted collagen and an acid soluble glycoprotein were purified from placentas of normal and diabetic human beings. Diabetic samples exhibit a significant increase in ketoamine-linked glucose while both amino acid and carbohydrate composition were unaffected. This excess non-enzymatic condensation of glucose on free amino-groups increased platelet aggregating potency of these proteins independantly of any modification in fiber morphology.