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Effects of trypsin on the platelet-aggregating activity of mouse tumor cells

Gasic, G.J.; Gasic, T.B.; Jimenez, S.A.

Thrombosis Research 10(1): 33-45

1977

ISSN/ISBN: 0049-3848
PMID: 850902
Document Number: 118825
A platelet aggregating factor was found in cells of 2 mouse tumors and cell free supernatants released spontaneously by mammary tumor and sarcoma cells. The factor disappeared from cells after trypsin treatment and its recovery in the cell free supernatant depended on the degree of cell trypsinization. Activity of cells regenerated during subsequent incubation by a process requiring protein synthesis. The latter, and the fact that the nondialyzable cell free material was sensitive to heat and trypsin, suggest that it is a protein or a protein complex.

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Hara, Y.; Steiner, M.; Baldini, M.G. 1980: Characterization of the platelet-aggregating activity of tumor cells Cancer Research 40(4): 1217-1222
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Nelson, M.; Nelson, D.S. 1985: Stimulation of proliferation in mixed cultures of mouse tumor cells and nonimmune peritoneal cells. I. Occurrence of stimulation and cyclical variation in tumor cell activity Journal of the National Cancer Institute 74(3): 627-635
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Izumi, Y.; Usui, T.; Okazaki, T.; Mochizuki, T.; Ishikura, H.; Tashima, M.; Sawada, H.; Uchino, H. 1985: Effects of VP-16 on cell growth and metabolism of nucleic acids in mouse leukemia L-1210 cells and on the activity of DNA polymerase i of E. coli Nihon Ketsueki Gakkai Zasshi: Journal of Japan Haematological Society 48(6): 1371-1380
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Agadzhanian, G.I.; Grigorian, E.G.; Atabekian, M.R.; Danielian, M.A.; Khemchian, B.G. 1975: Relationship between the activity of trypsin and trypsin inhibitors in duodenal ulcer Vrachebnoe Delo 4: 28-30
Kitagawa, H.; Yamamoto, N.; Yamamoto, K.; Tanoue, K.; Kosaki, G.; Yamazaki, H. 1989: Involvement of platelet membrane glycoprotein Ib and glycoprotein IIb/IIIa complex in thrombin-dependent and -independent platelet aggregations induced by tumor cells Cancer Research 49(3): 537-541
Perchellet, E.M.; Jones, D.; Perchellet, J.P. 1990: Ability of the Ca2+ ionophores A23187 and ionomycin to mimic some of the effects of the tumor promoter 12-O-tetradecanoylphorbol-13-acetate on hydroperoxide production, ornithine decarboxylase activity, and DNA synthesis in mouse epidermis in vivo Cancer Research 50(18): 5806-5812
Sako, T.; Yuspa, S.H.; Herald, C.L.; Pettit, G.R.; Blumberg, P.M. 1987: Partial parallelism and partial blockade by bryostatin 1 of effects of phorbol ester tumor promoters on primary mouse epidermal cells Cancer Research 47(20): 5445-5450
Hager, J.C.; Spiegelman, S.; Ramanarayanan, M.; Bausch, J.; Galletti, P.M.; Calabresi, P. 1982: Tumor-associated antigens produced by mouse mammary tumor cells in artificial capillary culture Journal of the National Cancer Institute 69(6): 1359-1366
Egawa, K.; Kiyohara, T.; Tanino, T. 1982: Non-H-2 restriction specificity of tumor-regressor mouse sera with regard to their activity to inhibit tumor cell transplantation Japanese Journal of Experimental Medicine 52(5): 255-260
Ooka, T.; Hatano, Y.; Yamamoto, M.; Ogawa, K.; Saika, S. 1996: Protective effects of human urinary trypsin inhibitor against trypsin-induced relaxation in rat aorta Critical Care Medicine 24(11): 1903-1907
Le Pape, A.; Gutman, N.; Guitton, J.D.; Legrand, Y.; Muh, J.P. 1983: Non enzymatic glycosylation increases platelet aggregating potency of collagen from placenta of diabetic human beings Biochemical and Biophysical Research Communications 111(2): 602-610
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Kertscher, H.P.; Ostermann, G.; Hofmann, B. 1988: Synthesis and thrombocyte-aggregating action of a structural analog of platelet activating factor with a modified head group Die Pharmazie 43(3): 211
Rossowska, J.; Pajtasz-Piasecka, E.; Szyda, A.; Zietara, N.; Duś, D. 2007: Tissue localization of tumor antigen-loaded mouse dendritic cells applied as an anti-tumor vaccine and their influence on immune response Folia Histochemica et Cytobiologica 45(4): 349-355