In vitro effects of fructose-1,6-diphosphate on oxygen affinity and electrolyte equilibrium in human blood
Bernasconi, C.; Piolini, M.; Bozzini, F.; Ferraresi, I.; Agostoni, A.
Research Communications in Chemical Pathology and Pharmacology 42(2): 281-292
1983
ISSN/ISBN: 0034-5164 PMID: 6658191 Document Number: 219829
The in vitro effects of a solution of fructose-1,6-diphosphate on hemoglobin-oxygen affinity and electrolyte distribution between plasma and red cells were evaluated. Fructose-1,6-diphosphate increased intracellular pH and decreased extracellular pH. There were no shifts in Na+, K+, Ca++ and Cl- between plasma and red cells. Red cell content of 2,3-diphosphoglycerate remained unchanged, while P50 was reduced (as a consequence of the intracellular alkalosis). The therapeutical implications of these results are discussed.