Haemodynamic effects of induced hypotension with a nitroprusside-trimetaphan mixture
Wildsmith, J.A.; Sinclair, C.J.; Thorn, J.; MacRae, W.R.; Fagan, D.; Scott, D.B.
British Journal of Anaesthesia 55(5): 381-389
1983
ISSN/ISBN: 0007-0912 PMID: 6342636 Document Number: 218429
The hemodynamic effects of a 10:1 mixture of trimetaphan and nitroprusside were studied before and during the course of surgery, in 12 patients placed in 5.degree. reverse Trendelenburg position. Patients group. Heart rate increased, and stroke volume, peripheral resistance and central venous pressure decreased in both groups. The start of surgery was associated with a need to increase the dose of the hypotensive mixture, and with a further increase in heart rate and decrease in stroke volume. Levelling the operating table produced an increase in cardiac output and discontinuation of the mixture resulted in a rapid return of all measurements towards control values.