Haemodynamic effects of labetalol-induced hypotension in the anaesthetized dog
Gustafson, C.; Ahlgren, I.; Aronsen, K.F.; Rosberg, B.
British Journal of Anaesthesia 53(6): 585-590
1981
ISSN/ISBN: 0007-0912 PMID: 7248122 Document Number: 168887
Central hemodynamic changes and regional blood flow were studied using the microsphere technique, during labetalol-induced hypotension in dogs anesthetized with pentobarbitone and fentanyl. Labetalol 15 mg/kg decreased mean arterial pressure from an average of 88 mm Hg to 47 mm Hg. Mean pulmonary arterial pressure was unchanged. Cardiac output was reduced by decrease in stroke volume, while heart rate remained unchanged. Myocardial blood flow decreased approximately in parallel with left ventricular work. Perfusion of the brain and kidneys was unchanged.