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Glutathione participation in the regulation of methanol metabolism in yeasts

Ubiĭvovk, V.M.; Bystrykh, L.V.; Trotsenko, I.A.

Mikrobiologiia 52(3): 383-387

1983

ISSN/ISBN: 0026-3656
PMID: 6621419
Document Number: 217405
The activity of enzymes involved in methanol oxidation and assimilation as well as the levels of formaldehyde and glutathione were determined during batch cultivation of Candida boidinii KD1 in a medium with methanol. The distribution of [14C]methanol between oxidative and biosynthetic processes in the yeast was analysed. Changes in the concentrations of formaldehyde and glutathione were found to correlate with the activity of formaldehyde dehydrogenase. The results indicate that an increase in the concentration of reduced glutathione (GSH) at the early logarithmic phase of the yeast growth stimulates formaldehyde oxidation via formate to carbon dioxide whereas a subsequent decrease in the concentration of GSH favours formaldehyde assimilation.

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