Endorphin-containing cells in the gastric antral mucosa in duodenal ulcer
Zverkov, I.V.; Vinogradov, V.A.; Smagin, V.G.
Biulleten' Eksperimental'noi Biologii i Meditsiny 96(10): 32-34
1983
ISSN/ISBN: 0365-9615 PMID: 6194833 Document Number: 215909
Immunohistochemical staining with the use of peroxidase-antiperoxidase was applied to study cells producing gamma- and alpha-endorphines in the gastric antral mucosa in duodenal ulcer. The cells producing gamma-endorphines were discovered to be mainly located in the epithelium of the cervical and upper third of the pyloric glands and to be alike G-cells producing gastrin. The cells producing alpha-endorphine were found both in the epithelium of the upper third of the gastric pyloric glands and in the gastric mucosa lamina proper. In peptic ulcer, there was an almost two-fold increase in the amount of gamma-endorphine-producing cells and diminution of epithelial endocrine cells producing alpha-endorphine.