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Evaluation of the liver function in workers of the vinyl resin plant

Kalemba, K.

Medycyna Pracy 34(3): 211-217

1983

ISSN/ISBN: 0465-5893
PMID: 6645935
Document Number: 214651
187 workers exposed to vinyl chloride (VC) were examined. The control group consisted of workers of the same plant but not exposed to vinyl chloride. In all workers biochemical liver function tests were performed. The results showed no damaging influence of VC on the liver cells membrane. A slight increase of the aminotransferases (ALAT, AspAT) activity was noticed only in alcohol drinking persons. The most important changes of the glutamyltranspeptidase activity were found. Increased activity of this enzyme was noticed in 84 persons. The results suggest the induction of the glutamyltranspeptidase (GGTP) activity by VC after exclusion of the effects of other agents like cholestase, barbiturates, ethyl alcohol, as well as the effects of carcinogenesis.

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