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Suppression of the macrophage function in mice in experimental Tahyña virus infection

Vargin, V.V.; Semenov, B.F.

Voprosy Virusologii 2: 235-238

1983

ISSN/ISBN: 0507-4088
PMID: 6603071
Document Number: 213216
The effect of Tahyña virus on the phagocytic activity of macrophages of BALB/c mice and their capacity to transmit the antigenic stimulus was studied. The phagocytic activity of mononuclear cells of different localization in Tahyña virus-infected mice was shown to vary. The capacity for elimination of Indian ink particles from the blood stream associated mainly with the function of liver macrophages in asymptomatic infection increases 24 hours postinoculation, then gets back to normal, and decreases on day 7. At the same time, no disorders in the phagocytosis of heterologous red cells by peritoneal macrophages were observed. In the period of maximum inhibition of humoral response to sheep red cells (days 4-7 of the test) the infected mice exhibited the most marked disorders in the capacity of peritoneal macrophages to transmit the antigenic stimulus in intact syngeneic recipients. It is this defect which appears to underlie the suppression of immune response to heterologous antigens caused by Tahyña virus.

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