Macrophage ultrastructure in the focus of experimental inflammation in genetically diabetic mice
Radostina, A.I.; Kharchenko, M.N.; Sirill Vambo
Arkhiv Patologii 56(1): 65-70
1994
ISSN/ISBN: 0004-1955 PMID: 8204057 Document Number: 426595
Mice of the strain C57BL/KsJ db+/db+ with a genetically predetermined diabetes mellitus type II were used. Experimental inflammation was produced by a subcutaneous administration of celloidin globules. Less developed synthetic and secretory apparatus and a decrease of cytoplasmic microprocesses formation are observed in the macrophages at both early (1 day) and late (14 days) periods in the diabetic animals. Besides that, less total size of the lysosomal apparatus at early periods and overloading of the cytoplasm with a non-degradated phagocytized material at late periods are observed in diabetic mice. This is considered as a morphological basis of the mononuclear phagocyte function decrease in diabetes mellitus.