A morphological analysis of a new mutant mice with paralytic club feet, peroneal muscular atrophy (pma)
Nakamura, M.; Hayashi, H.; Kurata, Y.; Mitta, M.; Ohkawa, A.; Ono, K.; Shiosaka, S.; Tohyama, M.; Esaki, K.
Journal für Hirnforschung 24(6): 659-670
1983
ISSN/ISBN: 0021-8359 PMID: 6672099 Document Number: 211899
To determine the pathomechanism of the condition of CF 1 mutant mice which present paralytic club feet, anatomicohistological analysis (conventional histological staining, silver impregnation, cholinesterase staining, and retrograde tracer technique of horseradish peroxidase (HRP)) were carried out. CF 1 homozygotic mutant mice lacked the common peroneal nerve, while tibial nerve is larger than that of normal mice when they were compared at the similar levels of the posterior limbs. Anterior and lateral crural muscles of the homozygotic mutant mice except for peroneus longus and brevis muscles showed large group muscle atrophy. HRP study indicated that the number of HRP labeled cells after injection of HRP into the anterior and lateral crural muscles decreased remarkably in number in the homozygotic mutant mice, comparing with that of the normal mice.