The effect of epsilon-aminocaproic acid on the normalization of embolizing fatty matter in the rabbit lung following experimental fractures. a polarized light study
Modugno, P.
Archivio Per le Scienze Mediche 140(2): 159-164
1983
ISSN/ISBN: 0004-0312 PMID: 6882191 Document Number: 210368
It has been confirmed that epsilon-aminocaproic acid (EACA), an inhibitor of fibrinolysis, reduced the incidence of fat embolism in the lung of rabbits with experimental bone fractures. Microscopic specimens of lungs, examined under polarized light, demonstrated the reduced amounts of lipoid materials that were prevalently undergraded. The action of the drug is owed to the inhibition of some primary mechanisms, involved in the genesis and diffusion of post-traumatic fat embolism.