Mechanism of the vasodilator action of kavinton on the cerebral vessels
Plotnikov, M.B.; Kotov, A.N.
Farmakologiia i Toksikologiia 46(6): 36-39
1983
ISSN/ISBN: 0014-8318 PMID: 6653756 Document Number: 208948
Experiments on human middle cerebral and cat internal maxillary arteries have shown high vasodilative activity of cavinton. The mechanism of the vasodilative action of the drug involves inhibition of the ingress of exocellular calcium via electrogenic and chemosensitive channels, suppression of calcium mobilization from the intracellular depot with depolarization of the membranes of vascular smooth cells and a decrease in phosphodiesterase activity.