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Suppression of acid secretion and plasma level of a once-daily dose of omeprazole

Müller, P.; Seitz, H.K.; Simon, B.; Dammann, H.G.

Arzneimittel-Forschung 33(12): 1685-1686

1983

ISSN/ISBN: 0004-4172
PMID: 6686775
Document Number: 208875
The effect of 5-methoxy-2-[( (4-methoxy-3,5-dimethyl-2-pyridinyl)-methyl]sulphinyl)-1H- benzimidazole (omeprazole) on gastric acid secretion after repeated administration to healthy volunteers has been studied. Omeprazole in a dose of 30 mg given once daily for nine days suppressed acid secretion continuously, the inhibitory effect stabilising after five days. Omeprazole was absorbed and rapidly cleared from plasma; the inhibitory effect was related to the area under the plasma concentration-time curve.

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