The late reaction following bronchial provocation with house dust mite allergen. Dependence on arachidonic acid metabolism
Fairfax, A.J.; Hanson, J.M.; Morley, J.
Clinical and Experimental Immunology 52(2): 393-398
1983
ISSN/ISBN: 0009-9104 PMID: 6861377 Document Number: 208303
The involvement of arachidonic acid metabolism in early and late bronchial reactions was studied in 4 asthmatic subjects sensitive to Dermatophagoides pteronyssinus. Pretreatment with either indomethacin (an inhibitor of the cyclo-oxygenase pathway) or benoxaprofen (an inhibitor of both cyclo-oxygenase and lipoxygenase pathways) failed to affect the amplitude; but did produce some foreshortening of the early response to allergen. If benoxaprofen is an effective inhibitor of SRS-A [slow-reacting substance of anaphylaxis] formation in vivo, then these observations question the role of SRS-A as a spasmogen in allergen-induced bronchospasm. Both drugs were effective inhibitors of the late reaction, implying involvement of cyclo-oxygenase products (endoperoxides, prostaglandins or thromboxanes) in the genesis of a late response to allergen.