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Interrelation of animal genotype and viral strain characteristics to the course of experimental tick-borne encephalitis

Larina, G.I.; Levkovich, E.N.

Voprosy Virusologii 3: 345-348

1983

ISSN/ISBN: 0507-4088
PMID: 6613092
Document Number: 208003
Differences in the susceptibility to a single subcutaneous inoculation of tick-borne encephalitis (TBE) virus, features of immune response and development of resistance were studied in animals of one species but 2 genotypes (mouse lines CBA and C57BL). In the formation of resistance, the determining factors include the degree of susceptibility, specific sensitization of the animal to the definite antigen, and the level of specific microglobulins. No resistance is formed in C57BL mice highly sensitive to TBE virus antigen.

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