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Effect of chronic use of antidepressants on the state of benzodiazepine receptors in the mouse brain

Rozhanets, V.V.; Rusakov, D.I.; Danchev, N.D.; Val'dman, A.V.

Biulleten' Eksperimental'noi Biologii i Meditsiny 96(7): 46-48

1983

ISSN/ISBN: 0365-9615
PMID: 6307423
Document Number: 206583
A study was made of the effect of a two-week administration of chlorimipramine, zimelidine and a morpholine derivative on benzodiazepine receptors of the mouse brain. The animals which received antidepressants demonstrated a significant increase in the binding sites of 3H-flunitrazepam without any changes in the dissociation constant as compared to control. The data on the evoked aggressiveness and latency of tonic corasole convulsions in the antidepressant-treated animals support the functional importance of the discovered changes in benzodiazepine receptors.

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