Autoradiographic studies on binding of glycolate esters with muscarinic cholinergic receptors in mouse brain
Ye, S.Z.; Li, G.F.; Chi, Z.Q.
Zhongguo Yao Li Xue Bao 3(1): 1-5
1982
ISSN/ISBN: 0253-9756 PMID: 6211895 Document Number: 190450
Muscarinic cholinergic receptors determined by the autoradiographic localization of a potent, muscarinic cholinergic antagonist [3H]QNB [3-quinuclinidyl benzilate] were studied in mouse brain. Higher densities of Ag grains were seen over nucleus caudatus putamen, dendritic regions in the hippocampus, nucleus septi lateralis, nucleus accumbens and pyriform cortex. The greatest density of receptors was observed in nucleus caudatus putamen. If mice were i.p. injected with glycolate esters, the density of grains in striatum regions was reduced. Displacement potencies of [3H]QNB binding to mouse brain by glycolate esters correlated with their central anticholinergic potencies. The anticholinergic effect of these glycolate esters closely correlated with muscarinic receptor affinity.