Analysis of cell lines obtained from tumors induced in Syrian hamsters by SA7 adenovirus and its DNA
Tiunnikov, T.I.; Ponomareva, T.I.; Dreĭzin, R.S.; Karmysheva, V.I.; Zolotarskaia, E.E.
Voprosy Virusologii 28(5): 607-611
1983
ISSN/ISBN: 0507-4088 PMID: 6659476 Document Number: 206141
Four cell lines derived from tumors induced by adenovirus SA7, its DNA (intact and fragmented with restrictase Sal-1), as well as isolated C-Sal-1 fragment (19.5% of genome) containing oncogene were studied. All the cell lines had the phenotypic markers of tumor cells, similar tumorigenicity, and produced T- and S-antigens. The line derived from the tumor induced by intact DNA contained the smallest adenovirus SA7 genome region (12%) which suggests that the information required for the synthesis of T and S antigens of adenovirus SA7 lies within the limits of this genome region.