Study of the organotropic and oncotropic properties of human type 16 adenovirus in the body of Syrian hamsters and mice
Frol'tsova, A.E.; Gibadulin, R.A.; Korchak, O.B.; Baryshnikov, A.I.
Voprosy Virusologii 5: 563-567
1975
ISSN/ISBN: 0507-4088 PMID: 174323 Document Number: 87414
Human adenovirus type 16 was studied in Syrian hamsters bearing SV40 virus induced transplantable tumour and in mice of Black line with Lewis cancer. Despite its tropism to the tumour tissue, the virus injected into the blood stream was first accumulated in the lung tissue and in organs of the reticuloendothelial system (the spleen and liver). When the tumour was in the lung tissue of mice, the virus content in it was much higher than in a similar tumour of subcutaneous localization.