Characteristics of the NK cells in Syrian hamsters carrying tumors with varying metastatic and resistance-suppressing activity
Kliuchareva, T.E.; Matveeva, V.A.
Biulleten' Eksperimental'noi Biologii i Meditsiny 99(6): 732-734
1985
ISSN/ISBN: 0365-9615 PMID: 4016267 Document Number: 250013
Experiments in vivo and in vitro were made to study the effects of HETR-MLN-8 and HETR tumor cells differing in metastatic ability and inhibition of the natural host resistance to tumor on cytotoxic activity of NK from Syrian hamsters. Marked inhibition of cytotoxicity and ability for interferon activation was detected in NK isolated from tumors (as compared with blood), with that inhibition being far more pronounced in highly malignant HETR-MLN-8 tumors. This may indicate a direct inhibitory action of the tumor or its products on NK cytotoxicity. The in-vitro competition inhibition test yielded results showing that HETR-MLN-8 cells capable of in-vivo inhibition of the natural host resistance to the tumor also display much more demonstrable ability for in-vitro inhibition of NK cytotoxicity as compared to HETR cells.