Cervical intraepithelial neoplasia recurrence after conization in HIV-positive and HIV-negative women
Lima, M.I.ês.; Tafuri, A.; Araújo, A.C.; de Miranda Lima, L.; Melo, V.H.
International Journal of Gynaecology and Obstetrics the Official Organ of the International Federation of Gynaecology and Obstetrics 104(2): 100-104
2009
ISSN/ISBN: 0020-7292 PMID: 19062013 DOI: 10.1016/j.ijgo.2008.10.009Document Number: 205718
To evaluate the recurrence rates of cervical intraepithelial neoplasia (CIN) in a cohort of HIV-infected and noninfected women who underwent the loop electrosurgical excision procedure (LEEP). A prospective cohort study of 94 HIV-positive and 107 HIV-negative women, both with CIN, treated with LEEP. The diagnosis of recurrence was established after biopsy. The Kaplan-Meier method was used for survival analysis and multivariate analyses were carried out using the Cox proportional hazards regression model. There was a predominance of low-grade lesions in HIV-positive compared with HIV-negative women (P<0.01). Recurrence was more frequent with compromised margins and glandular involvement (P<0.01). A multivariate analysis showed that HIV-infection, glandular involvement, and positive margins were independently associated with recurrence of lesions. Recurrence rate of CIN in HIV-positive women was higher than in HIV-negative women. The factors associated with recurrence were HIV infection, glandular involvement, and positive margins.
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