A model of oligomeric enzymes explaining stepwise kinetic curves
Shevelev, E.L.; Gol'dshteĭn, B.N.; Markovich, D.S.; Vol'kenshteĭn, M.V.
Molekuliarnaia Biologiia 17(6): 1249-1254
1983
ISSN/ISBN: 0026-8984 PMID: 6656753 Document Number: 203789
The complex kinetics of some oligomeric enzymes has been analysed. For interpreting such kinetics a theoretical model of an oligomeric enzyme is suggested, which is a modification of the "flip-flop" mechanism considered by Lazdunski et al. in 1971. Using our model, one can qualitatively interpret stepwise kinetic curves, i.e. the curves with few intermediate plateaus. Such curves are known from literature but have not exhaustively been explained. It is supposed that the enzyme kinetic curves can sometimes be of non-differential functions. The model used can also be applied to the kinetics of polyenzyme complexes.