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Model building in pharmacokinetics/Part V: Simulation of blood level curves following repetitive dosing and their experimental verification

Hammer, R.; Bozler, G.; Heinzel, G.; Koss, F.W.

Arzneimittel-Forschung 27(4a): 928-931

1977

ISSN/ISBN: 0004-4172
PMID: 577860
Document Number: 112151
An equation is given to describe the plasma level curve of any linear compartment model following multiple dosing of various doses after various time intervals. The equation is especially suitable to be used with desk top computers equipped with a plotting device. A dosage regimen can be simulated using the parameters derived from single dose experiments. Experimental check-up of the predicted curves is necessary and illustrated by two examples. Systematic deviations from the prediction indicate changes in the biological system, e.g., in absorption, by enzyme induction, saturable processes, etc.

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