Repetitive mucosal trauma promotes colon cancer in experimental rat model
Viñas Salas, J.; Piñol Felis, C.; Fermiñan, A.; Egido, R.; Pérez-Holanda, S.; Biendicho, P.; Buenestado, J.; Reñé Espinet, J.
Revista Espanola de Enfermedades Digestivas Organo Oficial de la Sociedad Espanola de Patologia Digestiva 93(3): 140-147
2001
ISSN/ISBN: 1130-0108 PMID: 11469074 Document Number: 532041
Objective: to investigate the effect of repetitive mucosal trauma, anastomosis and intestinal content on experimental colonic carcinogenesis as there is the possibility than non- specific colon lesions can promote cancer. Material and method: we performed to sixty female Sprague-Dawley rats a 4 cm colon loop defunctionalization with double colostomy (traumatic site). Intestinal continuity was restored with an end-to-end colo-colic silk anastomosis. The surviving 47 rats were divided in 3 groups: Group A: 27 rats treated with DMH. Group B: 10 rats treated with EDTA and Group C: Control of 10 rats. Animals were sacrificed 31-32 weeks after surgery for macro and micropathological studies. Results: in group A appeared 60 tumours: 44 in the functional colon, 20 of them in the anastomotic site; 8 in the non traumatised defunctionalized segment and 18 in the traumatised segment (p<0.05). Conclusions: a) continuous microtraumas on colonic mucosa in rats are cancer promotional factors; b) silk suture in anastomosis promotes cancer.