The efficacy of a new formulation of trimethoprim and sulphadiazine in acute exacerbations of chronic bronchitis
Robertson, C.E.; Ford, M.J.; Munro, J.F.; Gould, J.C.; Langford, D.T.; Bernstein, L.S.
Methods and Findings in Experimental and Clinical Pharmacology 5(2): 127-129
1983
ISSN/ISBN: 0379-0355 PMID: 6876943 Document Number: 203539
Thirty-four acute exacerbations of chronic bronchitis were treated using a new formulation of trimethoprim and sulphadiazine. Significant bacterial isolates were obtained in 18 exacerbations of which 12 comprised Haemophilus influenzae. Adverse effects of treatment, principally nausea, occurred in 5 patients. A satisfactory clinical response in association with the achievement of mucoid sputum was obtained in 94% and the mean time for sputum conversion of 3.8 days compares favourably with other antibiotics.