Free radical mechanism of action of pyrimido-triazine antibiotics
Orlov, V.S.; Bogdanov, G.N.; Emanuél', N.M.; Esipov, S.E.; Navashin, S.M.
Bioorganicheskaia Khimiia 9(4): 556-560
1983
ISSN/ISBN: 0132-3423 PMID: 6091693 Document Number: 203448
EPR spectra of anion radicals were recorded as a result of chemical or enzymatic reduction at various pH of the pyrimide-triazine antibiotics. These anion radicals easily form superoxide radicals in the presence of oxygen. Apparently, a higher selectivity of reumycin action is due to difference in the redox potentials of the neutral and ionized antibiotic forms. A possibility of enhance the reumycin potency may involve the pH lowering inside the tumor cells, for example, by glucose injections.