Pneumococcal serotyping in France. Development (1978-1982) and vaccine covering
Geslin, P.; Sissia, G.; Frémaux, A.
Bulletin Europeen de Physiopathologie Respiratoire 19(2): 199-203
1983
ISSN/ISBN: 0395-3890 PMID: 6871498 Document Number: 203204
From 09/1977 till 08/1982, 2,449 pneumococcus strains coming from Paris or province hospitals were typed according to the Danish system with antisera from the Copenhagen Statens Serum Institut by counter-immunoelectrophoresis for the first 900 and by capsular swelling afterwards. For the whole, the first 14 types or groups are in order: 19 (348), 6 (261), 23 (231), 3 (205), 1 (158), 14 (104), 9 (103), 18 (94), 7 (82), 11 (82), 15 (82), 4 (74), 8 (63), 10 (55), and make up 79.3% of the whole. For the 687 strains isolated from haemocultures or from cerebrospinal fluids, the first 14 types or groups are in order: 1 (95), 19 (69), 6 (56), 23 (49), 4 (47), 3 (44), 7 (42), 18 (40), 9 (35), 5 (32), 14 (30), 8 (27), 15 (18), 24 (13), and make up 86.9% of these strains. The annual variations for these 687 strains are slight as regards the 14 most frequent groups and types: the type I is always first, except for one year. The definition of serotypes in the groups for 261 strains isolated from cerebrospinal fluids or from haemocultures, in 1981 and 1982, allowed a study of the "vaccinal covering". It is 64.75% for the marketed tetradecavalent vaccine and 82.75% for a 23 valency vaccine defined according to international serotype statements.