Conjugate pneumococcal vaccine in HIV-infected Ugandans and the effect of past receipt of polysaccharide vaccine
Miiro, G.; Kayhty, H.; Watera, C.; Tolmie, H.; Whitworth, J.A.G.; Gilks, C.F.; French, N.
Journal of Infectious Diseases 192(10): 1801-1805
2005
ISSN/ISBN: 0022-1899 PMID: 16235180 DOI: 10.1086/497144Document Number: 259517
We investigated the immunogenicity of a 7-valent conjugate pneumococcal vaccine (CPV) in human immunodeficiency virus - infected Ugandan adults and measured the effect of past pneumococcal polysaccharide vaccine (PPV) receipt given as part of a controlled trial. Two doses of CPV, 4 weeks apart, were given to 54 past PPV recipients and 55 past placebo recipients (84% female; median CD4 cell count, 251 cells/mu L [range, 1 - 936 cells/mu L]). Postvaccination anticapsular immunoglobulin G (IgG) concentrations were directly correlated with CD4 cell count (P < .01 for all serotypes). There were significant increases in anticapsular IgG concentrations for all serotypes after the first dose (P < .01) and for all serotypes except 14 and 9V after the second dose. Past receipt of PPV did not affect vaccine response.