Pharmacokinetics of fluorocarbon blood substitute
Ding, X.C.; Chen, B.W.; Shen, J.F.; Gu, W.H.; Cao, W.J.
Zhongguo Yao Li Xue Bao 4(4): 262-264
1983
ISSN/ISBN: 0253-9756 PMID: 6230872 Document Number: 202647
The pharmacokinetics of fluorocarbon emulsions (FCE) was investigated in rats and monkeys [Macaca mulatta]. The blood levels of FCE after i.v. 15 g/kg in 4 monkeys decreased in 2 phases, the distributive phase and the eliminative phase, with half-lives [t1/2] of 3.8 and 44 h, respectively. Pharmacokinetic parameters were calculated according to the 2-compartment open model. The blood FCE levels data fter i.v. FCE 9 g/kg in rats adequately fitted to 1-compartment open model, t1/2 = 10 h. After i.v. FCE 9 g/kg in rats the highest FCE level was found in spleen, moderate in liver and lowest in kidneys, indicating an accumulation in the reticuloendothelial system. FCE disappeared completely from all organs in 2 mo., which was in agreement with the results of pharmacokinetic analysis.