Profile of primary resistance in HIV-1-infected treatment-naive individuals from Western India
Lall, M.; Gupta, R.M.; Sen, S.; Kapila, K.; Tripathy, S.P.; Paranjape, R.S.
Aids Research and Human Retroviruses 24(7): 987-990
2008
ISSN/ISBN: 1931-8405 PMID: 18593351 DOI: 10.1089/aid.2008.0079Document Number: 202606
The majority of the HIV drug resistance (HIVDR) testing studies have focused on subtype B virus. The predominance of subtype C in the Indian subcontinent along with greater access to antiretroviral therapy (ART) necessitates studies on HIVDR genotyping. We determined the prevalence of mutations associated with protease inhibitors (PI), nucleoside reverse transcriptase inhibitors (NRTI), and nonnucleoside reverse transcriptase inhibitors (NNRTI) from plasma of 40 antiretroviral drug-naive study participants in Indian HIV-1 pol gene sequences. Of these, 36 sequences belonged to subtype C, two to subtype A1, and two were subtype A1C recombinants. The heterosexual route was the most common route of transmission. Drug resistance-associated mutations were observed in 10% (4/40) of the study participants. The resistance mutation observed in the protease gene was V82A, whereas in the RT gene, M41L, D67N, M184V, and A98G were documented. This is the first study reporting major protease mutations by genotyping in ART-naive individuals from western India.