Scanning electron microscopy in the diagnosis of bronchogenic squamous cell and small cell anaplastic carcinoma
Tosi, P.; Luzi, P.; Leoncini, L.; Sforza, V.; Gotti, G.; Grossi, A.
Applied Pathology 1(2): 82-88
1983
ISSN/ISBN: 0252-1172 PMID: 6331475 Document Number: 202493
The authors believe that differential diagnostic aspects between poorly-differentiated squamous cell carcinoma (PDS) and small cell anaplastic carcinoma (SCA) may be shown by scanning electron microscopy (SEM) analysis of 'thick' sections from routine paraffin-embedded tissues. In 8 'sample' cases features were demonstrated which were typical of PDS (well-defined outlines of cells, intercellular bridges) and of SCA (fairly smooth cell surface, nuclei in relief, a spongy, granular-like appearance of cytoplasm).