Circadian rhythm of ventilatory parameters of intrinsic asthma in clinical remission
De Benedetto, F.; Cervone, M.; De Blasio, E.; De Matthaeis, G.; Fuciarelli, R.; Luciano, A.; Sborgia, M.; Sensi, S.
Bollettino della Societa Italiana di Biologia Sperimentale 59(8): 1082-1085
1983
ISSN/ISBN: 0037-8771 PMID: 6626343 Document Number: 202417
In six subjects with intrinsic asthma in clinical remission, time-structure of ventilatory parameters has been evaluated in order to evaluate: 1) which indexes present statistically significant circadian fluctuations; 2) if phase-shifts occur in comparison with normal subjects. After a period of synchronization of 7 days (L/D: 07.30-23.00; meal timing at 08.00, 13.00 and 20.30) all subjects have been studied by spirometry, flow-volume loop and Raw determination 6 times in a 24-hr period at constant intervals of 4 hrs. The results have been evaluated by macroscopic and microscopic analysis statistical significant fluctuations have been shown in these functional indexes: MEF50, Raw, SRaw, SGaw, FRC and RV; no phase-shifts occurred in comparison with normal subjects. On the contrary a circadian rhythm has not been shown in FVC, FEV1, and PEF. Therefore only the effort-independent test should be used to study correctly the bronchial tone.