Comparative binding studies of anticonvulsant drugs to bovine serum albumin
Dal Pozzo, A.; Acquasaliente, M.; Tajana, A.
Il Farmaco; Edizione Scientifica 38(8): 609-618
1983
ISSN/ISBN: 0430-0920 PMID: 6617856 Document Number: 200733
The ability of a new anticonvulsant drug, denzimol, to interact with bovine serum proteins has been studied, in comparison with diphenylhydantoin and carbamazepine. Albumin proved to be the protein fraction responsible for the binding. The association constants were determined in vitro by means of equilibrium dialysis. Additional investigations showed that there was no consistent inhibition by denzimol of the other two drugs binding and vice versa. These data were obtained as a preliminary evaluation of the influence of protein binding in vivo.