Theory of organotropism of roentgen contrast media
Sergeev, P.V.; Shimanovskiĭ, N.L.; Belykh, A.G.
Farmakologiia i Toksikologiia 46(5): 61-72
1983
ISSN/ISBN: 0014-8318 PMID: 6354745 Document Number: 199939
The authors summarize their own and reported data on the reasons for selective tropism for definite organs of organic iodine-containing radiographic contrast agents (RCA). Offer a theory that explains the organotropism of RCA and that is based on the physicochemical characteristics of their interrelationship with blood plasma proteins and target cells. Provide a classification of RCA the basis of which is formed by the chemical structure of the compounds in question. Review the physicochemical bases for interaction of RCA with blood serum proteins, plasma membranes and intracellular proteins of the excretory organs.