Gonadotrophins stimulate lactate production by rat cumulus and granulosa cells
Billig, H.; Hedin, L.; Magnusson, C.
Acta Endocrinologica 103(4): 562-566
1983
ISSN/ISBN: 0001-5598 PMID: 6412500 Document Number: 199102
Oocyte-cumulus complexes and mural granulosa cells, respectively, isolated from pre-ovulatory rat follicles and cultured in lactate-free medium showed a continuous accumulation of lactate during a 1-7 h incubation. Lactate production was stimulated by gonadotrophins, both when administered in vivo and in vitro, with the exception that lutropin given in vivo did not affect granulosa cell lactate production. Since the oocyte is known to have specific demands on energy substrate, the lactate produced apparently is important for the growing and maturing oocyte.