Ehrlich tumor cells stimulate T-cell production of interferon-gamma and are resistant to autocrine nitric oxide
Bel'skiĭ, I.P.; Bel'skaia, N.V.; Danilets, M.G.; Trofimova, E.S.; Patrushev, V.K.; Agafonov, V.I.
Voprosy Onkologii 50(6): 689-692
2004
ISSN/ISBN: 0507-3758 PMID: 15755064 Document Number: 575768
Ehrlich tumor cells released factors which activated T-cell production of interferon-gamma and triggered a mechanism of nitric oxide (NO) production instead of interferon-gamma. When cultured in vitro, they produced NO without stimulation and responded to interferon-gamma by an output rate of NO significantly greater than that in bone marrow cells. Unlike P-815 cells, those of Ehrlich tumor proved resistant to autocrine NO.
Document emailed within 1 workday
Related Documents
Deng, X.; Wu, J.; Guo, X.; Han, X.; Ding, X. 2000: Effect of 8-bromo-cyclic AMP on neuron specific enolase, heat shock protein, nitric oxide, nitric oxide synthase and nitric oxide synthase mRNA in human retinoblastoma HXO-Rb44 cells and cell differentiation Chinese Medical Journal 113(3): 198-200Gabrilovac, J.; Balog, T.; Andreis, A. 2003: Dynorphin-A(1-17) decreases nitric oxide release and cytotoxicity induced with lipopolysaccharide plus interferon-gamma in murine macrophage cell line J774 Biomedicine and PharmacoTherapy 57(8): 351-358
Bandyopadhyay, A.; Chakder, S.; Rattan, S. 1997: Regulation of inducible and neuronal nitric oxide synthase gene expression by interferon-gamma and VIP American Journal of Physiology 272(6 Pt 1): C1790-C1797
Choi, E.-M. 2007: Apigenin increases osteoblastic differentiation and inhibits tumor necrosis factor-alpha-induced production of interleukin-6 and nitric oxide in osteoblastic MC3T3-E1 cells Die Pharmazie 62(3): 216-220
Mullet, D.; Fertel, R.H.; Kniss, D.; Cox, G.W. 1997: An increase in intracellular cyclic AMP modulates nitric oxide production in IFN-gamma-treated macrophages Journal of Immunology 158(2): 897-904
Raponi, G.; Ghezzi, M.C.; Mancini, C. 1997: The release of tumor necrosis factor alpha (TNF-alpha) by interferon gamma (IFN-gamma) induced THP-1 cells stimulated with smooth lipopolysaccharide is inhibited by MAbs against HLA-DR and CD14 receptors on the effector cell New Microbiologica 20(1): 1-6
Petruson, K.; Stalfors, J.; Jacobsson, K.E.; Ny, L.; Petruson, B. 2005: Nitric oxide production in the sphenoidal sinus by the inducible and constitutive isozymes of nitric oxide synthase Rhinology 43(1): 18-23
Tötemeyer, S.; Sheppard, M.; Lloyd, A.; Roper, D.; Dowson, C.; Underhill, D.; Murray, P.; Maskell, D.; Bryant, C. 2006: IFN-gamma enhances production of nitric oxide from macrophages via a mechanism that depends on nucleotide oligomerization domain-2 Journal of Immunology 176(8): 4804-4810
Yamamoto, T.; Katayama, I.; Nishioka, K. 1998: Nitric oxide production and inducible nitric oxide synthase expression in systemic sclerosis Journal of Rheumatology 25(2): 314-317
Trachtman, H.; Jacques, C.; Citron, J.; Futterweit, S. 1996: Effect of triiodothyronine on nitric oxide production in mesangial cells and renal tubular epithelial cells Research Communications in Molecular Pathology and Pharmacology 93(1): 69-78
Rodríguez-Arnao, M.D.; Rodríguez-Sánchez, A.; Rodríguez-Arnao, J.; Dulín- Iñiguez, E.; Cano, J.M.Bellón.; Muñoz-Fernández, M.A. 2003: Undetectable levels of tumor necrosis factor-alpha, nitric oxide and inadequate expression of inducible nitric oxide synthase in congenital hypothyroidism European Cytokine Network 14(1): 65-68
Suzuki, Y.; Chen, L.P.; Liu, C.M.; Morita, T.; Wheelock, E.F. 1989: Immune regulation of the L5178Y murine tumor-dormant state: induction of cell- and soluble factor-mediated inhibition of tumor cell growth by tumor necrosis factor and gamma-interferon Cancer Research 49(8): 2028-2033
Józkowicz, A.; Płytycz, B. 1997: Nitric oxide production by cells infiltrating amphibian skin grafts Folia Biologica 45(1-2): 73-78
Song, X-zu.; Bi, Z-gang.; Xu, A-e. 2006: Green tea polyphenol epigallocatechin-3-gallate inhibits the expression of nitric oxide synthase and generation of nitric oxide induced by ultraviolet B in HaCaT cells Chinese Medical Journal 119(4): 282-287
Gorbachev, A.V.; Kobayashi, H.; Kudo, D.; Tannenbaum, C.S.; Finke, J.H.; Shu, S.; Farber, J.M.; Fairchild, R.L. 2007: CXC chemokine ligand 9/monokine induced by IFN-gamma production by tumor cells is critical for T cell-mediated suppression of cutaneous tumors Journal of Immunology 178(4): 2278-2286
Langrehr, J.M.; Müller, A.R.; Markus, P.M.; Simmons, R.L.; Hoffman, R.A. 1991: FK 506 inhibits nitric oxide production by cells infiltrating sponge matrix allografts Transplantation Proceedings 23(6): 3260-3261
Tamir, S.; deRojas-Walker, T.; Gal, A.; Weller, A.H.; Li, X.; Fox, J.G.; Wogan, G.N.; Tannenbaum, S.R. 1995: Nitric oxide production in relation to spontaneous B-cell lymphoma and myositis in SJL mice Cancer Research 55(19): 4391-4397
Onozaki, K.; Urawa, H.; Tamatani, T.; Iwamura, Y.; Hashimoto, T.; Baba, T.; Suzuki, H.; Yamada, M.; Yamamoto, S.; Oppenheim, J.J. 1988: Synergistic interactions of interleukin 1, interferon-beta, and tumor necrosis factor in terminally differentiating a mouse myeloid leukemic cell line (M1). Evidence that interferon-beta is an autocrine differentiating factor Journal of Immunology 140(1): 112-119
Lu, M.; Zheng, F.; Huang, H.N. 1987: Morphometric study on sensitization by hematoporphyrin derivative in Ehrlich ascites tumor cells irradiated by gamma-ray Zhonghua Zhong Liu Za Zhi 9(5): 325-327; 19
Asaumi, J.; Kawasaki, S.; Kuroda, M.; Takeda, Y.; Kishi, K.; Hiraki, Y. 1999: Intracellular accumulation and retention of calcein in Ehrlich ascites tumor cells and their adriamycin-resistant strain Anticancer Research 19(5b): 4311-4314