The effect of lithium, imipramine and chlorpromazine on the membrane bound enzyme phosphatidylethanolamine methyltransferase
Ziemsen, B.; Agarwal, D.P.; Hoo, J.J.; Goedde, H.W.
Arzneimittel-Forschung 33(11): 1523-1524
1983
ISSN/ISBN: 0004-4172 PMID: 6686446 Document Number: 197748
The activity of phosphatidylethanolamine methyltransferase (PMT) in disrupted human erythrocytes and ghost cells was inhibited by lithium (Li+), imipramine and chlorpromazine. There was no inhibitory effect of the drugs in concentrations similar to the average therapeutic blood levels. Li+ exerted an inhibition on PMT activity in hemolysates at concentrations 8 times the average therapeutic level whereas chlorpromazine and imipramine showed an inhibitory effect on PMT in hemolysates at 10(3) fold their respective therapeutic serum level.