M- and p-halobenzoyl derivatives of p-halo-DL-phenylalanine as inhibitors in a microbial antitumor prescreen
Otani, T.T.; Briley, M.R.
Research Communications in Chemical Pathology and Pharmacology 40(2): 325-328
1983
ISSN/ISBN: 0034-5164 PMID: 6410473 Document Number: 197661
Meta- and p-halobenzoyl-p-halo-phenylalanine compounds were prepared and tested for growth-inhibitory activity in a Lactobacillus casei system. The activity of 13 of the most active of these compounds, reported here, was greater than that of any other acyl derivatives of amino acid analogs previously studied in this system and was from 2 to 8 times greater than that of 6-mercaptopurine, a known antitumor agent.