Thermal enhancement of bleomycin-induced tumour growth delay: the effect of dose fractionation
Hassanzadeh, M.; Chapman, I.V.
European Journal of Cancer and Clinical Oncology 19(11): 1517-1519
1983
ISSN/ISBN: 0277-5379 PMID: 6196201 Document Number: 197204
The influence of hyperthermia on bleomycin induced growth delay of a syngeneic murine carcinoma was studied in both simultaneous and sequential schedules for single and multi-fraction drug dose. The results reveal thermal potentiation of drug-induced growth delay if treatment is given simultaneously. This observed potentiation is independent of single or multi-fraction drug administration. Sequential pre-heating treatment resulted in only additive growth rate depression for single and 2-fraction drug doses. However, when the drug dose was given in 3 fractions a significant thermal potentiation was observed for both simultaneous and sequential schedules.