Changes in immune reactivity during growth of an adenovirus 12-induced transplantable tumour in CBA mice
Britten, V.; Underwood, J.C.
Experientia 37(5): 504-505
1981
ISSN/ISBN: 0014-4754 PMID: 7250325 Document Number: 179891
Early suppression, followed by a period of enhancement and finally, suppression, was seen when the spleen cell response to T and B cell mitogens was monitored during growth of an adenovirus 12-induced tumor in CBA black mice. The macrophage content of the tumor changed with time, and these fluctuations correlated with the ability of tumor tissue extracts to enhance the normal spleen cell response to mitogen.
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