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Effects of estrogen-progesterone implants on the blood coagulation system of lambs

Al-Baker, J.; Keeton, K.S.

American Journal of Veterinary Research 43(10): 1837-1839

1982

ISSN/ISBN: 0002-9645
PMID: 7149387
Document Number: 196157
Results of a study on the effects of estrogen-progesterone implants on the coagulation system in lambs indicated that fibrinogen concentration and factors II, VII and IX activities were increased, whereas antithrombin III levels were lowered. The prothrombin time and activated partial thromboplastin time were decreased. These changes, together with the exaggerated response of platelet aggregation to ADP, identified the development of a hypercoagulable state in the lambs. [This study has applications to the study of the adverse effects of oral contraceptives in the coagulation system.].

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