Complement activation in chronic liver disease
Munoz, L.E.; De Villiers, D.; Markham, D.; Whaley, K.; Thomas, H.C.
Clinical and Experimental Immunology 47(3): 548-554
1982
ISSN/ISBN: 0009-9104 PMID: 7083631 Document Number: 195498
Patients with HbsAg 3d concentrations and changes in the serum concentrations of the C components consistent with activation of the classical and alternative pathways. In these patients the concentrations of the regulatory proteins, C3b inactivator (C3bINA) and .beta.IH globulin, are normal. Patients with HBsAg negative CALD and alcohol induced liver disease (ALD) exhibit no evidence of an increased level of C system activation. In these patients diminished serum concentrations of C components appear to be related to diminished hepatic synthetic function. C4 synthesis may be specifically reduced in autoimmune chronic active liver disease.