Sex hormone changes in chronic liver disease: a matched study of alcoholic versus non-alcoholic liver disease
Bannister, P.; Oakes, J.; Sheridan, P.; Losowsky, M.S.
Quarterly Journal of Medicine 63(240): 305-313
1987
ISSN/ISBN: 0033-5622 PMID: 2960998 Document Number: 290562
Men with liver disease are hypogonadal and feminized. European workers consider the liver disease itself to be the major factor but American workers blame alcohol consumption. We studied sexual dysfunction and sex hormones in three matched groups of men; controls (n = 22), those with alcoholic liver disease (n = 21), and those with non-alcoholic liver disease (n = 21). Men with alcoholic liver disease had more sexual dysfunction. Testosterone and androstenedione concentrations were lower and oestradiol and dehydroepiandrosterone sulphate levels were raised in the liver disease groups. The changes were greatest in the alcoholic liver disease group. In this, the first controlled study, liver disease per se appears to cause sexual dysfunction and sex hormone changes but these changes are amplified by ethanol.